CD44 and Hyaluronan Promote the Bone Morphogenetic Protein 7 Signaling Response in Murine Chondrocytes
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چکیده
منابع مشابه
Bone morphogenetic protein signaling in the murine distraction osteogenesis model.
A murine distraction osteogenesis model was standardized to allow analysis of the molecular pathways associated with postnatal de novo bone formation. The authors examined the presence and expression of Bone Morphogenetic Proteins (BMPs) -2, -3, -4, -6 and -7, and the BMP receptors Alk3 and Alk6 at different stages. Strong signals were detected for BMP-4 at the end of the distraction period and...
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متن کاملCD44 modulates Smad1 activation in the BMP-7 signaling pathway
Bone morphogenetic protein 7 (BMP-7) regulates cellular metabolism in embryonic and adult tissues. Signal transduction occurs through the activation of intracellular Smad proteins. In this paper, using a yeast two-hybrid screen, Smad1 was found to interact with the cytoplasmic domain of CD44, a receptor for the extracellular matrix macromolecule hyaluronan. Coimmunoprecipitation experiments con...
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ژورنال
عنوان ژورنال: Arthritis & Rheumatology
سال: 2014
ISSN: 2326-5191
DOI: 10.1002/art.38388